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[1]魏文娟,张君毅,尹传奇,等.两种聚合物型手性固定相的分离特性[J].武汉工程大学学报,2008,(03):1-3.
　WEI Wen juan,ZHANG Jun yi,YIN Chuan qi,et al.Enantioseparation properties of two polymertypechiral stationary phases[J].Journal of Wuhan Institute of Technology,2008,(03):1-3.
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两种聚合物型手性固定相的分离特性
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2008年03期
页码:
1-3
栏目:
化学与化学工程
出版日期:
2008-03-31

文章信息/Info

Title:
Enantioseparation properties of two polymertype
chiral stationary phases
文章编号:
16742869(2008)03000103
作者:
魏文娟; 张君毅; 尹传奇; 柏正武*
武汉工程大学化工与制药学院，绿色化工过程省部共建教育部重点实验室，湖北 武汉 430074
Author(s):
WEI Wenjuan;  ZHANG Junyi;  YIN Chuanqi;  BAI Zhengwu
School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology,
Laboratory for Green Chemical Process of Ministry of Education, Wuhan 430074, China
关键词:
手性固定相; 共聚物; 手性识别;  定量分析
Keywords:
chiral stationary phases;  enantioseparation property;  chiral resolution;  quantitative determination
分类号:
O 657.7
DOI:
-
文献标志码:
A
摘要:
为研究(1S,2R)(+)2氨基二苯基乙醇与对苯二异氰酸酯的二元共聚物和(1S,2R)(+)2氨基二苯基乙醇、对苯二异氰酸酯及对苯二甲酰氯三元共聚物这两种手性固定相所识别手性化合物的结构特点，用一系列手性样品对其分离能力进行了测试，讨论了这两种固定相的构效关系，并用光学纯的手性化合物为标准品，用其混旋体为样品进行分离.结果表明：前一种固定相可用来进行对映体过量的定量分析．
Abstract:
To investigate the enantioseparation properties of two chiral stationary phases (CSPs), which were derived from the copolymerization of (1S,2R)(+)2amino1,2diphenylethanol and 1,4phenylene diisocyanate; and the copolymerization of (1S,2R)(+)2amino1,2diphenylethanol, 1,4phenylene diisocyanate and terephthaloyl chloride, the enantioseparation ability of these two chiral stationary phases were evaluated with a series of chiral analytes. The relationship of structural features between chiral compounds separated and the CSPs were discussed. Using an optically pure chiral compound as the standard, its racemate as the sample, the separation results showed that the CSPs could be applied for quantitative determination of enantiomer excess.

参考文献/References:

［1］Cancelliere G D, Acquarica I, Gaspqrrini F, et al. Synthesis and applications of novel, highly efficient HPLC chiral stationary phase: a chiral dimension in drug research analysis\[J\]. PSTT, 1999, 2(12): 484492.
［2］王晓东,姚金水.手性识别及氨基酸类手性固定相的研究进展\[J\].有机化学, 2006, 26(7)：912921.
［3］孟磊，袁黎明.纤维素及其衍生物作为高效液相色谱手性固定相的研究进展\[J\].化学试剂，2001,23(4)：220223.
［4］达世禄,徐伟,董亚琼.手性高效液相色谱固定相\[J\].化学通报,1997,(2) : 3334.
［5］Hofstetter H, Hofstetter O. Antibodies as tailormade chiral selectors for detection and separation of stereoisomers\[J\]. Trends Anal Chem, 2005, 24(10):869879.
［6］Huang S H, Bai Z W, Yin C Q, et al. Synthesis of polymer type chiral stationary phases and their enantioseparation evaluation by highperformance liquid chromatography\[J\]. Chirality, 2007, 19(2): 129140.
［7］Huang S H, Bai Z W, Pan Z Q, et al. DendrimerLike Chiral Stationary Phases Derived from (1R,2R)(+)1,2Diphenylethylenediamine and 1,3,5Benzenetricarbonyl Trichloride\[J\]. Chromatographia, 2006, 64(1112): 641646.
［8］Huang S H, Bai Z W, Yin C Q. Covalently Bonding Chiral Polyurethane on Aminated Silica Gel: A New Strategy to Prepare Chiral Stationary Phasse For High Performance Liquid Chromatography \[J\]. Chin J Polym Sci, 2006, 24(2): 107114.
［9］黄少华.选择体为聚合物及树型分子的手性固定相的研究：\[学位论文\].武汉：武汉化工学院化工与制药学院，2005：4653.

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备注/Memo

备注/Memo:
收稿日期：2008031
2基金项目：国家自然科学基金项目（20675061）
作者简介：魏文娟（1983），女，江苏徐州人，硕士研究生．研究方向：手性化合物的制备及其分离．
指导老师：柏正武，教授，硕士生导师．研究方向：手性化合物的制备及其分离．*通信联系人
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