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[1]谌颉.空气流量控制在阿维菌素发酵过程中的应用[J].武汉工程大学学报,2008,(03):8-10.
 CHEN Jie.Application of aeration control in the avermectin fermentation[J].Journal of Wuhan Institute of Technology,2008,(03):8-10.
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空气流量控制在阿维菌素发酵过程中的应用(/HTML)
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2008年03期
页码:
8-10
栏目:
化学与化学工程
出版日期:
2008-03-31

文章信息/Info

Title:
Application of aeration control in the avermectin fermentation
文章编号:
16742869(2008)03000803
作者:
谌颉
武汉工程大学化工与制药学院,新型反应器与绿色化学工艺重点实验室,湖北 武汉 430074
Author(s):
CHEN Jie
School of Chemical Engineering and Pharmarcy, Wuhan Institute of Technology,
Hubei Key Lab of Novel Reactor and Green Chemical Technology, Wuhan 430074, China
关键词:
质谱仪阿维链霉菌发酵过程通气
Keywords:
mass spectrometer S. avermitilis fermentation process aeration
分类号:
TQ 920.6
DOI:
-
文献标志码:
A
摘要:
在S. avermitilis 发酵过程中引入质谱仪进行尾气的在线测定.发现正常过程产素期临界通气量为1 600m3/h;前期的OUR数值可以用于预测发酵正常与否;在非正常批次,产素期在尾气数据指导下利用空气流量限制发酵的初级代谢水平,起到部分恢复产素速率的效果.
Abstract:
Method of using mass spectrometer to the exhaust gas online analysis was successfully applied into fermentation processes of avermectin in China for the first time. The critical inlet air flux was found to be 1 600 m3/h, and OUR value in prophase could be used to indicate future trend of the batch. For an abnormal batch, with the restriction of primary metabolism under guidance of the exhaust gas data, yielding rate of avermectin was restored to a normal level.

参考文献/References:

[1]朱立元. 林可霉素发酵生产过程中空气流量控制的研究\[J\]. 中国抗生素杂志,2001,26(5):393394.
[2]谌颉,储炬,庄英萍,等. 质谱仪在avermectin发酵过程中的应用\[J\]. 中国抗生素杂志,2004,29(1):47.
[3]储炬, 李有荣. 现代工业发酵调控学\[M\]. 北京:化学工业出版社,2002.
[4]Gbewonyo K, Jain D, Hunt G,et al. Online analysis of avermectin fermentation cell growth kinetics in an industrial Pilot plant \[J\]. Biotechnol Bioeng,1989,34(2):234241.
[5]Schulman M, Valentino D, Hensens O. Biosynthesis of the avermectins by Streptomyces avermitilis: incorporation of labeled precursors \[J\]. J Antibiotics,1986,39(4):541549.

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备注/Memo

备注/Memo:
收稿日期:20070508
作者简介:谌颉(1976),男,湖北武汉人,博士.
研究方向:发酵过程优化.
更新日期/Last Update: