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[1]张桥,鄢国平,程巳雪.点击化学反应原位制备海藻酸钠水凝胶[J].武汉工程大学学报,2011,(07):14-16.
　ZHANG Qiao,YAN Guoping,CHENG Sixue.Preparation of alginate hydrogels via “click” chemistry[J].Journal of Wuhan Institute of Technology,2011,(07):14-16.
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2011年07期
页码:
14-16
栏目:
材料科学与工程
出版日期:
2011-08-30

文章信息/Info

Title:
Preparation of alginate hydrogels via “click” chemistry
文章编号:
16742869(2011)07001403
作者:
张桥1;  鄢国平1; 程巳雪2
1．武汉工程大学材料科学与工程学院，湖北 武汉 430074；
2．武汉大学化学与分子科学学院生物医用高分子材料教育部重点实验室，湖北 武汉 430072
Author(s):
ZHANG Qiao1;  YAN Guoping1;  CHENG Sixue2
1. School of Material Science and Engineering, Wuhan Institute of Technology, Wuhan 430074, China;
2.? Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry,
Wuhan University, Wuhan 430072, China
关键词:
点击化学; 海藻酸钠; 水凝胶; 溶胀; 生物材料
Keywords:
click chemistry;  alginate;  hydrogels;  swelling;  biomaterials
分类号:
O636.1
DOI:
-
文献标志码:
AAdoi:10.3969/j.issn.16742869.2011.07.004
摘要:
合成了叠氮基和炔基海藻酸钠，并利用亚铜离子催化的叠氮基与炔基之间的环加成点击化学反应制备了海藻酸钠水凝胶.用FT-IR对水凝胶的结构进行了表征.扫描电镜和溶胀行为的研究表明通过点击化学制备的海藻酸钠水凝胶具有较大的孔径和pH敏感性，是潜在的生物医用材料.与其它通过化学交联制备海藻酸钠水凝胶的方法相比，本方法制备条件温和、快捷方便.
Abstract:
Alginate derivatives bearing side chains endowed with either azide or alkyne terminal functionality have been synthesized. When the solutions of tow derivatives were mixed together in the presence of Cu (I) catalyst, the alginate hydrogels were formed by the click chemistry between azide and alkyne. The chemical structures of the alginate derivatives and hydrogels were characterized by FTIR. The results of SEM and swelling behavior exhibited that the hydrogels had a macroporous structure as well as pH responsive. In comparison to other methods of preparation alginate hydrogels via chemical crosslinks, this strategy is quicker and more convenience.

参考文献/References:

［1］鲁路，刘新星，童真.海藻酸盐水凝胶化及其在软骨组织工程和药物控释领域的应用［J］.高分子学报，2010，12:13511358.
［2］Augst A D，Kong H K，Mooney D J. Alginate hydrogels as biomaterials［J］.Macromolecular Bioscience，2006（6）:623633.
［3］Rowley J A，Madlambayan G，Mooney D J. Alginate hydrogels as synthetic extracellular matrix materials［J］.Biomaterials，1999，20（1）:4553.
［4］Bouhadir K H，Hausman D S，Mooney D J. Synthesis of crosslinked poly(aldehyde guluronate) hydrogels［J］.Polymer，1999，40:35753584.
［5］Parrish B，Breitenkamp R B，Emrick T. PEG and Peptidegrafted Aliphatic Polyesters by Click Chemistry［J］. Journal of the American Chemical Society，2005，127:74047410.
［6］Xu X D，Chen C S，Wang Z C，et al. “Click” chemistry for in situ formation of thermoresponsive P(NIPAAmcoHEMA)based hydrogels［J］.Journal of Polymer Science: Part A: Polymer Chmistry，2008，46:52635277.
［7］杨奇志，刘佳，蒋序林. “点击”化学在生物医用高分子中的应用［J］.化学进展，2010，22:23772387.
［8］Crescenzi V，Cornelio L，Meo C D，et al. Novel hydrogels via click chemistry: synthesis and potential biomedical applications［J］. Biomacromolecules，2007，8:18441850.
［9］徐玉婷，张灿.基于“点击”化学反应的聚乙二醇壳聚糖接枝共聚物的合成及其表征［J］. 中国药科大学学报，2010，41（6）:481486.
［10］Zhang X Z，Yang Y Y， Chung T S，et al. Preparation and characterization of the macroporous poly(Nisopropylacrylamide) hydrogel with fast response［J］.Langmuir，2001，17:60946099.

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