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[1]黎璐平,杨微,夏旭英,等.维生素E自乳化固体分散体的制备[J].武汉工程大学学报,2012,(2):24-27.
　LI Lu\|ping,YANG Wei,XIA Xu\|ying,et al.Preparation of vitamin E self\|emulsifying solid dispersion[J].Journal of Wuhan Institute of Technology,2012,(2):24-27.
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维生素E自乳化固体分散体的制备(/HTML)
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2012年2期
页码:
24-27
栏目:
化学与化学工程
出版日期:
2012-03-10

文章信息/Info

Title:
Preparation of vitamin E self\|emulsifying solid dispersion
文章编号:
16742869(2012)2002404
作者:
黎璐平; 杨微; 夏旭英; 陈雅芬; 刘永琼*
武汉工程大学环境与化工清洁生产实验教学示范中心，
绿色化工过程省部共建教育部重点实验室，湖北 武汉 430074
Author(s):
LI Lu\|ping; YANG Wei; XIA Xu\|ying; CHEN Ya\|fen; LIU Yong\|qiong
Wuhan Institute of Technology of environment and chemical of clean production experimental teaching demonstration center，
Wuhan Institute of Technology; Key laboratory for Green Chemical Process of Ministry of Education， Wuhan 430074,China
关键词:
维生素E; 自乳化; 固体分散体; 制备; 溶出速率; 紫外吸收光谱; 粒径
Keywords:
vitamin E; self\|emulsifying;  solid dispersion; prepare; dissolution rate; UV absorption spectra; particle size
分类号:
R9799
DOI:
-
文献标志码:
AAdoi:103969/jissn1674286920122005
摘要:
采用固体分散体技术来提高维生素E的生物利用度以自乳化辅料和载体A为载体，采用熔融法，制备维生素E自乳化固体分散体（VE\|SEDS），通过溶出度实验，考察其溶出速率，并以测定紫外吸收光谱和粒径来鉴别药物在载体中的存在状态.研究结果表明:当维生素E自乳化制剂∶载体A（w/w)=1∶8时制得的维生素E自乳化固体分散体平均粒径为449 nm，累计溶出百分率在5、20 min分别达到647%、911%，溶出效果明显优于VE(0%).将维生素E制成自乳化固体分散体后，提高了维生素E自乳化制剂的稳定性，增加了维生素E在人工肠液中的溶出度.
Abstract:
 By the technology of solid dispersion to improvre the bioavailability of vitamin E. By the melting of solid dispersion and using self\|emulsifying materials and A materials as the carrier to prepare solid self\|emulsifying of vitamin E， and by measured the UV absorption spectra and the diameter of particle to verification the solid self\|emulsifying of Vitamin E Results showed that the average particle size of vitamin E self\|emulsifying solid dispersion can achieve 449 nm when the self\|emulsifying of Vitamin E to A materials (w/w) is equal to 1∶8, and the dissolution rate can achieve 647%and 911% at the time of 5 min and 20 min，respectively The dissolution is better than VE（0%）After Vitamin E is made of self\|emulsifying solid dispersion, it can increase the stability of self\|emulsifying of vitamin E and the solubility of vitamin E in water

参考文献/References:

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