[1] LASHEEN W, WALSH D. The cancer anorexia- cachexia syndrome: myth or reality?[J]. Support Care Cancer , 2010,18(1):265–272. [2] BOZZETTI F, MARIANI L. Defining and classifying cancer cachexia: a proposal by the SCRINIO Working Group[J]. Journal of Parenteral & Enteral Nutrition, 2009, 33(4):361-367. [3] PRESTON T, FEARON K C H, MCMILLAN D C, et al. Effect of ibuprofen on the acute-phase response and protein metabolism in patients with cancer and weight loss[J]. British Journal of Surgery, 1995, 82(2):229-234. [4] WIGMORE S J,FALCONER J S, PLESTER C E, et al. Ibuprofen reduces energy expenditure and acute-phase protein production compared with placebo in pancreatic cancer patients[J]. British Journal of Cancer, 1995, 72(1):185-188. [5] DEWYS W D, BEGG C, LAVIN P T, et al. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group[J]. American Journal of Medicine, 1980, 69(4):491-497. [6] TAZI E, ERRIHANI H. Treatment of cachexia in oncology[J]. Indian Journal of Palliative Care, 2010, 16(3):129-137. [7] DAVIS M P, DICKERSON D, DAVIS M P, et al. Cachexia and anorexia: cancer’s covert killer[J]. Supportive Care Cancer, 2000, 8(3):180-187. [8] BLUM D,OMLIN A, FEARON K, et al. Evolving classification systems for cancer cachexia: ready for clinical practice?[J]. Supportive Care in Cancer, 2010, 18(3):273-279. [9] LEBLANCl T W?,NIPP?R D?,?RUSHING C N?,?et al.Correlation between the international consensus definition of the Cancer Anorexia-Cachexia Syndrome (CACS) and patient-centered outcomes in advanced non-small cell lung cancer[J]. Pain Symptom Manage,??2015, 49(4):680-689. [10] APRO M, ARENDS J, BOZZETTI F, et al. Early recognition of malnutrition and cachexia in the cancer patient: a position paper of?a European School of Oncology Task Force [J]. Ann Oncol, 2014, 25(8): 1492-1499. [11] KORBONITS M, GOLDSTONE A P, GUEORGUIEV M, et al. Ghrelin—a hormone with multiple functions[J]. Frontiers in Neuroendocrinology, 2004, 25(1):27-68. [12] ESPOSITO A, CRISCITIELLO C, GEKAO L, et al. Mechanisms of anorexia-cachexia syndrome and rational for treatment with selective ghrelin receptor agonist[J]. Cancer Treat Rev,2015,41(9):793-797. [13] DIXIT V D, SCHAFFER E M, PYLE R S, et al. Ghrelin inhibits leptin-and activation-induced proinflammatory cytokine expression by human monocytes and T cells[J]. Journal of Clinical Investigation, 2004, 114(1):57-66. [14] LISSONI P, PAOLOROSSI F, TANCINI G, et al. Is there a role for melatonin in the treatment of neoplastic cachexia?[J]. European Journal of Cancer, 1996, 32A(8):1340-1343. [15] GARCIA J M, POLVINO W J. Effect on body and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: results of a phase I, randomized, placebo-controlled, multiple- dose study in healthy volunteers [J]. Oncologist,1996,12(5):594-600. [16] LISSONI P. Biochemotherapy with standard chemotherapies plus the pineal hormone melatonin in the treatment of advanced solid neoplasms[J]. Pathologie-biologie, 2007, 55(3/4):201-204. [17] DEL F E, DEV R, HUI D, et al. Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial[J]. Journal of Clinical Oncology Official Journal of the American Society of Clinical Oncology, 2013, 31(10):1271-1276. [18] WANG X Y, LIU B Y, YOU S. Research progress on transaminase in the synthesis of chiral compounds[J]. Journal of Shenyang Pharmaceutical University, 2014, 31(4):313-324. [19] NICOLINI A, FWRRARI P, MASONI M C, et al. Malnutrition, anorexia and cachexia in cancer patients: A mini-review on pathogenesis and treatment[J]. Biomedecine & pharmacotherapie, 2013, 67(8):807-817. [20] ANDERSON L J, ALBRECHT E D, GARCIA J M. Update on management of cancer-related cachexia [J]. Current oncology reports , 2017,19 (1): 3. [21] MA D F, SHUZHEN G,RONGBIN Y. Continuous synthesis of butyl acetate by using molecular sieve catalyst liquid phase[J]. Chemical World,1994,12(3):634-636. [22] CHAKRAVARTY P K, CHEN M H, NARGUND R, et al. Piperidines, pyrrolidines and hexahydro-1H- azepines promote release of growth hormone: US, US5804578[P]. 1998-09-08. [23] MAKINO T, MATSUMOTO M, SUZUKI Y, et al. Semi-synthesis of human ghrelin:combination of recombinant peptide synthesis with chemical synthesis of O-acylated fragmant[J]. Journal of Peptide Science, 2004, 10(10):14. [24] BALDWIN J J, CLAREMON D A, TICE C M, et al. Piperidine and morpholine renin inhibitors: US, US7858624[P]. 2010. [26] 皮政林,彭永利. 二-(双胍基对苯基)甲烷的合成及表征[J]. 武汉工程大学学报, 2017, 39(4):326-330,393. [27] PULEO L, MARINI P, AVALLONE R, et al. Synthesis and pharmacological evaluation of indolinone derivatives as novel ghrelin receptor antagonists[J]. Bioorganic & Medicinal Chemistry, 2012, 20(18):5623-5636.