|本期目录/Table of Contents|

[1]王柳,巨修练*.2，5二取代1，3，4噁二唑类杂环化合物的合成、表征[J].武汉工程大学学报,2010,(05):34-37.[doi:10.3969/j.issn.16742869.2010.05.010]
　WANG Liu,JU Xiu lian.Synthesis and characterization of 2，5disubstituted1,3,4oxadiazoles heterocyclic compounds[J].Journal of Wuhan Institute of Technology,2010,(05):34-37.[doi:10.3969/j.issn.16742869.2010.05.010]
点击复制

2，5二取代1，3，4噁二唑类杂环化合物的合成、表征(/HTML)
分享到：

《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2010年05期
页码:
34-37
栏目:
化学与化学工程
出版日期:
2010-05-31

文章信息/Info

Title:
Synthesis and characterization of 2，5disubstituted1,3,4
oxadiazoles heterocyclic compounds
文章编号:
16742869(2010)05003404
作者:
王柳;  巨修练*
武汉工程大学化工与制药学院，湖北省新型反应器与绿色化学工艺重点实验室，湖北 武汉 430074
Author(s):
WANG Liu; JU Xiulian
Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology, School of Chemical
Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430074, China
关键词:
2; 5二取代1; 3; 4噁二唑; 合成; 表征
Keywords:
2; 5disubstituted1; 3; 4oxadiazole; synthesis; characterization
分类号:
O626.414
DOI:
10.3969/j.issn.16742869.2010.05.010
文献标志码:
A
摘要:
分别以水杨酸和邻氨基苯甲酸为起始原料，设计合成了6个未见文献报道的2，5二取代1，3，4噁二唑类杂环化合物.其结构经1H NMR、EIMS和元素分析表征.
Abstract:
Six novel 2,5disubstituted1,3,4oxadiazoles were designed and synthesized by starting materials of salicylic acid and orthoaminobenzoic acid. Target structures were characterized by 1H NMR, EIMS and elemental analysis.

参考文献/References:

［1］尤启冬.药物化学［M］.北京:化学工业出版社,2004:409.
［2］Palaska E, �瘙塁ahin G, Kelicen P, et al. Synthesis and antiinflammatory activity of 1acylthiosemicarbazides, 1,3,4oxadiazoles, 1,3,4thiadiazoles and 1,2,4triazole3thiones［J］. Il Farmaco, 2002, 57: 101107.
［3］Kocabalkanli A, Ate�瘙塂 ，tük G. Synthesis and evaluation of antibacterial activity of some 2［［α(4substituted benzoyloxy)αphenylacetyl or methylacetyl］ amino］5(4methoxyphenyl)1,3,4oxadiazoles［J］. Il Farmaco,2001, 56: 975979.
［4］Chen H, Li Z, Han Y. Synthesis and fungicidal activity against Rhizoctonia solani of 2alkyl(Alkylthio)5pyrazolyl1,3,4oxadiazoles (Thiadiazoles) ［J］. Agric Food Chem, 2000, 48: 53125315.
［5］Kiselyov A S, Semenova M, Semenovc V V, et al. Inhibitors of VEGF receptors1 and 2 based on the 2((pyridin4yl)ethyl)pyridine template［J］.J Bioorg Med Chem Lett,2006,16:19131919.
［6］Ouyang X, Piatnitski E L, Pattaropong V, et al. Oxadiazole derivati ves as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines［J］. Bioorg Med Chem Lett,2006,16:11911196.
［7］陈川,俞德超,滕理送．以VEGF／VEGFR为靶点的抗肿瘤药物的研究进展［J］.中国肿瘤生物治疗杂志,2007,14(3):293300.
［8］Zarghi A,Sayyed A Tabatabai, Mehrdad Faiz, et al. Synthesis and of anticomvulsant activity of new 2substituted5(2benzylthiophenyl)1,3,4oxadiazoles［J］.Bioorg Med Chem Lett,2005,15:18631865.
［9］Lankau HJ, Unverferth K, Grunwald C, et al. New GABAmodulating 1,2,4oxadiazolederivatives and their anticonvulsant activity［J］.European Journal of Medicinal Chemistry,2007(42): 873879.
［10］陈军,盛春泉,郑灿辉,等.VEGFR2活性腔性质以及与抑制剂的结合模式研究［J］.化学学报,2007,65(6):547552.
［11］谢兵,周光明.异硫氰酸苯酯的制备与应用［J］.化工时刊,2006,20(3):7174.
［12］王树清,高崇,李建华.对甲苯基苄基醚的合成［J］.精细石油化工进展,2005,6(1):3032.
［13］董恒山,杨世琰.2芳胺基5［1’氨基1’(4’’氯苯基) 1’,2’,3’三唑4’基］1,3,4噁二唑的合成［J］.有机化学,1998,18: 253258.

相似文献/References:

[1]刘安昌,刘芳,谭珍友,等.4氨基1，2，4三氮唑的合成[J].武汉工程大学学报,2008,(04):28.
　LIU An chang,LIU Fang,TAN Zhen you,et al.Study on the Synthesis of 4amino1,2,4triazole[J].Journal of Wuhan Institute of Technology,2008,(05):28.
[2]刘洋,黄齐茂*,尹传奇,等.碘比醇中间体的合成[J].武汉工程大学学报,2008,(02):27.
　LIU Yang,HUANG Qi mao,YIN Chuan qi,et al.Synthesis of intermediates of iobitridol[J].Journal of Wuhan Institute of Technology,2008,(05):27.
[3]王银平,胡学雷*,李雯,等.配合物［Eu(NO3)2(tpy)(H2O)3］NO3的合成和晶体结构[J].武汉工程大学学报,2010,(07):33.[doi:10.3969/j.issn.16742869.2010.07.008]
　WANG Yin pin,HU Xue lei*,LI Wen,et al.Synthesis and crystal structure of complex ［Eu(NO3)2(tpy)(H2O)3］NO3[J].Journal of Wuhan Institute of Technology,2010,(05):33.[doi:10.3969/j.issn.16742869.2010.07.008]
[4]王凯,黄婷,张天畅,等.2，5二氨基4，6二羟基嘧啶盐酸盐的合成[J].武汉工程大学学报,2011,(05):22.[doi::10.3969/j.issn.16742869.2011.05.007]
　WANG Kai*,HUANG Ting,ZHANG Tianchang,et al.Preparation of 2, 5diamino4, 6dihydroxypyrimidinehydrochloride[J].Journal of Wuhan Institute of Technology,2011,(05):22.[doi::10.3969/j.issn.16742869.2011.05.007]
[5]胡学雷,姜治平,于晓琪,等.多吡啶高氯酸盐的合成与晶体结构[J].武汉工程大学学报,2012,(8):11.[doi:103969/jissn16742869201208003]
　HU Xue lei,JIANG Zhi ping,YU Xiao qi,et al.Synthesis and crystal structure of multipyridylperchlorate[J].Journal of Wuhan Institute of Technology,2012,(05):11.[doi:103969/jissn16742869201208003]
[6]杨海涛１,曾天宇１,舒　畅２,等.２，２，３，３－四氟丙基－２，２，３，３，４，４，４－七氟丁基醚的合成工艺[J].武汉工程大学学报,2015,37(12):1.[doi:10. 3969/j. issn. 1674-2869. 2015. 12. 001]
　,,et al.Ｓｙｎｔｈｅｓｉｓ ｏｆ ２，２，３，３－ｔｅｔｒａｆｌｕｏｒｏｐｒｏｐｙｌ ２，２，３，３，４，４，４－ｈｅｐｔａｆｌｕｏｒｏｂｕｔｙｌ ｅｔｈｅｒ[J].Journal of Wuhan Institute of Technology,2015,37(05):1.[doi:10. 3969/j. issn. 1674-2869. 2015. 12. 001]
[7]张云飞,徐贵祥,刘　辉,等.2，4，6-三羟甲基苯酚钠改性脲醛树脂的制备与表征[J].武汉工程大学学报,2016,38(3):263.[doi:10. 3969/j. issn. 1674?2869. 2016. 03. 012]
　ZHANG Yunfei,XU Guixiang,LIU Hui,et al.Preparation and Characterization of Urea Formaldehyde Resins Modified by 2， 4， 6-trimethylol Sodium Phenate[J].Journal of Wuhan Institute of Technology,2016,38(05):263.[doi:10. 3969/j. issn. 1674?2869. 2016. 03. 012]
[8]张　琪,陶世鹏,马　姗,等.新型异喹啉衍生物的合成[J].武汉工程大学学报,2016,38(4):327.[doi:10. 3969/j. issn. 1674?2869. 2016. 04. 003]
　ZHANG Qi,TAO Shipeng,MA Shan,et al.Synthesis of Novel Isoquinoline Derivative[J].Journal of Wuhan Institute of Technology,2016,38(05):327.[doi:10. 3969/j. issn. 1674?2869. 2016. 04. 003]
[9]翟马跃,梁淑彩*,潘　宇,等.亚硝酸根的2，3-二氨基吩嗪荧光猝灭法测定[J].武汉工程大学学报,2016,38(05):431.[doi:10. 3969/j. issn. 1674?2869. 2016. 05. 004]
　ZHAI Mayue,LIANG Shucai*,PAN Yu,et al.Determination of Nitrite with 2， 3-Diamino-Phenazine by Fluorescence Quenching Method[J].Journal of Wuhan Institute of Technology,2016,38(05):431.[doi:10. 3969/j. issn. 1674?2869. 2016. 05. 004]
[10]付晓滨,陈云舟,李　欢,等.5-苯基-2H-1，2，3-三唑-4-羧酸的合成[J].武汉工程大学学报,2016,38(06):527.[doi:10. 3969/j. issn. 1674-2869. 2016. 06. 003]
　FU Xiaobin,CHEN Yunzhou,LI Huan,et al.Synthesis of 5-phenyl-2H-1，2，3-triazole-4-carboxylic acid[J].Journal of Wuhan Institute of Technology,2016,38(05):527.[doi:10. 3969/j. issn. 1674-2869. 2016. 06. 003]

备注/Memo

备注/Memo:
收稿日期：20100114作者简介：王柳（1984），女，湖北武汉人,硕士研究生.研究方向：药物合成.指导老师：巨修练，教授，博士，博士研究生导师.研究方向：药物合成.
更新日期/Last Update: