|本期目录/Table of Contents|

[1]方志文,陈达,王凯*,等.2苯氧乙胺盐酸盐的合成[J].武汉工程大学学报,2010,(11):22-24.[doi:10.3969/j.issn.16742869.2010.11.006]
　FANG Zhi wen,CHEN Da,WANG Kai,et al.Preparation of 2phenoxyethanamine hydrochloride[J].Journal of Wuhan Institute of Technology,2010,(11):22-24.[doi:10.3969/j.issn.16742869.2010.11.006]
点击复制

2苯氧乙胺盐酸盐的合成(/HTML)
分享到：

《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2010年11期
页码:
22-24
栏目:
化学与化学工程
出版日期:
2010-11-30

文章信息/Info

Title:
Preparation of 2phenoxyethanamine hydrochloride
文章编号:
16742869(2010)11002203
作者:
方志文1; 2; 陈达1; 王凯1*; 周巍1
1.湖北省新型反应器与绿色化学工艺重点实验室,武汉工程大学化工与制药学院,湖北 武汉 430074;
2.中国建筑第三工程局武汉中心医院药剂科,湖北 武汉 430070
Author(s):
FANG Zhiwen1; 2;  CHEN Da1;  WANG Kai1;  ZHOU Wei1
1.Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology,School of Chemical
Engineering & Pharmacy,Wuhan Institute of Technology,Wuhan 430074, China;
2.Department of Pharmaceutical Dosage,Wuhan Central Hospital of China Construction
Third Engineering Bureau,Wuhan 430070, China
关键词:
2苯氧乙胺; 氯代; 合成; 工艺改进
Keywords:
2phenoxyethylamine;  chlorination;  synthesis;  procedure innovation
分类号:
TQ463+.5
DOI:
10.3969/j.issn.16742869.2010.11.006
文献标志码:
A
摘要:
以乙醇胺为起始原料,经氯代制备2氯乙胺,与苯酚缩合合成2苯氧乙胺,再与盐酸成盐的新路线,总收率为75%;同时,对于以苯酚和环乙胺为原料制备2苯氧乙胺的合成中的反应溶剂、投料方式、后处理等工艺条件进行改进,使得产率从原来的46.5%提高到57%;新路线以及工艺改进,能较好满足工业化生产的需要.
Abstract:
A new synthetic route of 2phenoxyethylamine was explored that 2chloroethylamine was chlorinated with ethanolamine as the starting material,and it condensed with the phenol to obtain 2phenoxyethylamine to further form its hydrochloride,with a total yield of 75%. At the same time,the process of 2phenoxyethylamine was improved with the starting materials phenol and cyclohexylamine,which made the original yield from 46.5% to 57% through changing reaction solvent,adding mode,treatment process and so on. As a result,the new route and technology changes can meet the need of industrial production better.

参考文献/References:

［1］Wei Y S,George P S.Prepation of phenoxyethenmaine ［P］. US: 527612. 1994.
［2］Davis R,Whittington R,Bryson H M.Nefazodone,a review of its pharmacology and clinical efficacy in the management of major depression ［J］.Drugs,1997,53 (4): 608636.
［3］Stirton A J. Amines ［P］.Swiss: 273953. 1951.
［4］董新荣,杨建奎.5乙基4 (2苯氧乙基)1,2,4三唑3酮的合成［J］.精细化工中间体,2003,33(3):2325.
［5］Li Ai Jun,Zhou Xue Qin,Liu Dong Zhi. Improved synthesis of nefazodone from phenol ［J］. Transactions of Tianjin University,2006,12(4):48251.
［6］章小波,蒋永祥.抗抑郁药奈法唑酮中间体2苯氧乙胺的合成工艺改进［J］.精细化工中间体,2003,33(5):2829.
［7］Ulrich H,Emanuel P,Karl F Z. The action of alcohols ethylenimines (aziridines) synthesis of βamino ethers［J］.Bar,1964,97(2):510519.
［8］Wood,Thomas F. 1Amino2haloethanes from 2oxazolidones：US，2617825［P］.1952-11-11.

相似文献/References:

[1]巨修练１,２*,乔　恒１,等.４－［（４－氯－２－嘧啶基）氨基］苯腈的合成[J].武汉工程大学学报,2015,37(02):1.[doi:10. 3969/j. issn. 1674-2869. 2015. 02. 001]
　U,*,IAO,et al.Ｓｙｎｔｈｅｓｉｓ ｏｆ ４－（（４－ｃｈｌｏｒｏｐｙｒｉｍｉｄｉｎ－２－ｙｌ）ａｍｉｎｏ）ｂｅｎｚｏｎｉｔｒｉｌｅ[J].Journal of Wuhan Institute of Technology,2015,37(11):1.[doi:10. 3969/j. issn. 1674-2869. 2015. 02. 001]

备注/Memo

备注/Memo:
收稿日期：20100629基金项目：武汉工程大学科学研究基金(No.10092022)资助作者简介：方志文(1977)，女，硕士研究生，执业药师.研究方向：中间体合成以及药物制剂.指导老师：王凯，副教授，博士.研究方向：医药开发和过程控制.
更新日期/Last Update: