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[1]王凯,黄婷,张天畅,等.2，5二氨基4，6二羟基嘧啶盐酸盐的合成[J].武汉工程大学学报,2011,(05):22-24.[doi::10.3969/j.issn.16742869.2011.05.007]
　WANG Kai*,HUANG Ting,ZHANG Tianchang,et al.Preparation of 2, 5diamino4, 6dihydroxypyrimidinehydrochloride[J].Journal of Wuhan Institute of Technology,2011,(05):22-24.[doi::10.3969/j.issn.16742869.2011.05.007]
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2，5二氨基4，6二羟基嘧啶盐酸盐的合成
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2011年05期
页码:
22-24
栏目:
化学与化学工程
出版日期:
2011-05-31

文章信息/Info

Title:
Preparation of 2, 5diamino4, 6dihydroxypyrimidine
hydrochloride
文章编号:
16742869(2011)05002203
作者:
王凯1; 黄婷1; 张天畅2; 黄强1
1.武汉工程大学绿色化工过程教育部重点实验室, 湖北 武汉 430074；
2.荆楚理工学院生物工程学院，湖北 荆门 480000
Author(s):
WANG Kai1*;  HUANG Ting1;  ZHANG Tianchang2; HUANG Qiang1
1.Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan 430074，China；
2. Bioengineering College，Jingchu University of Technology，Jingmen 480000，China
关键词:
丙二酸二乙酯; 2; 5二氨基4; 6二羟基嘧啶; 合成
Keywords:
diethyl malonate;  2; 5diamino4; 6dihydroxypyrimidine;  preparation
分类号:
TQ460.31
DOI:
:10.3969/j.issn.16742869.2011.05.007
文献标志码:
A
摘要:
以丙二酸二乙酯和盐酸胍为起始原料，通过环合、硝化、还原、酸化得到2，5二氨基4，6二羟基嘧啶盐酸盐，其结构通过了熔点、MS、元素分析的确证；同时，对于反应条件和操作过程进行改进，有效地降低原料成本，简化操作过程，提高产品质量.
Abstract:
With diethyl malonate and guanidine hydrochloride as the starting material, 2,5diamino4,6dihydroxypyrimidine was prepared by cyclization, nitration, reduction and acid reaction and its structure was confirmed through the melting point, MS, elemental analysis. At the same time, some measures were taken to investigate the processing technology in the fields of reaction condition and operation procedures, which effectively reduced the material cost, simplified operation and improved product quality.

参考文献/References:

［1］Sun F F，Ma N，Li Z M，et al. 2Amino4(2, 2, 2trifluoroethoxy) pyrimidine［J］. Acta Cryst, 2006, E62: 38643865.
［2］马大有, 余聂芳. 新型2芳基氨基嘧啶衍生物的合成［J］. 有机化学, 2008, 28(8)： 14481453.
［3］Herry H C, Roland K R. Potential purine antagonists. XL. Synthesis of some 9aryl(alkyl)2, 6disubstituted purines［J］. J Am Chem Soc, 1958, 80 (11)： 27512755.
［4］Dunn D L, Skinner C G. Pyrimido［4,5b］［1,4］oxazines, 8oxadihydropteridines［J］. J Org Chem, 1975, 40(25)： 37133716.
［5］贾志涛, 张未星, 杜鹃, 等. 2氨基4，6二氯5甲酰氨基嘧啶的合成［J］. 合成化学, 2005, 13 (3)： 270272.

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备注/Memo

备注/Memo:
收稿日期：20100709作者简介：王凯(1976), 男, 湖北武汉人, 副教授, 博士. 研究方向:医药产品及中间体开发和技术革新.
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